PUBLICATIONS SYNTOPHAGY
PUBLICATIONS SYNTOPHAGY
PUBLICATIONS 2025
Fei, L., Liang, Y., Kintscher, U., Sigrist, S. J. (2025). Coupling of mitochondrial state with active zone plasticity in early brain aging. Redox Biology.79. https://doi: 10.1016/j.redox.2024.103454.Epub 2024 Dec 3. PMID: 39642596
Han, Y., Hacker, D., Donders, B. C., Parperis, C., Thuenauer, R., Leterrier, C., Grünewald, K., Mikhaylova, M. (2025). Unveiling the cell biology of hippocampal neurons with dendritic axon origin. Journal of Cell Biology, 224(1). https://doi: 10.1083/jcb.202403141
Huang S., Piao C., Zhao Z., Beuschel C.B., Turrel O., Toppe D., Sigrist S.J. (2025). Enhanced memory despite severe sleep loss in Drosophila insomniac mutants. PLoS Biol. 2025 Mar 20;23(3):e3003076. doi: 10.1371/journal.pbio.3003076. eCollection 2025 Mar. PMID: 40111981
Karpova, A., Hiesinger, R. P., Kuijpers, M., Albrecht, A., Kirstein, J., Andres-Alonso, M., Biermeier, A., Eickholt, B. J., Mikhaylova, M., Maglione, M., Montenegro-Venegas, C., Sigrist, S. J., Gundelfinger, E., D., Haucke, V., Kreutz, M. (2025). Neuronal autophagy in the control of synapse function. Neuron, 113. https://doi.org/10.1016/j.neuron.2025.01.019
Kochlamazashvili, G., Swaminathan, A., Stumpf, A., Kumar, A, Posor, Y., Schmitz, D., Haucke, V., Kuijpers, M. (2025) Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function. Proceedings of the National Academy of Sciences of the United States of America. 29;122(17). doi: 10.1073/pnas.2413651122
Kunz, M., Schott D., Wunderling, T., Halloul, M., Hansen, C., Albrecht, A., Braun-Dullaeus, R. C. (2025). Embryonic heart development as an immersive experience: Unveiling learning effects and influential factors in virtual learning environments. Computers in Biology and Medicine. 187. https://doi: 10.1016/j.compbiomed.2024.109638
Liang Y., Krivograd A., Hofer S.J., Kollipara L., Züllig T., Sickmann A., Eisenberg T., Sigrist S.J. (2025). Spermidine supplementation and protein restriction protect from organismal and brain aging independently. Aging (Albany NY). 2025 Jun 7;17(6):1429-1451. doi: 10.18632/aging.206267. Epub 2025 Jun 7. PMID: 40489973
Lützkendorf, J., Matkovic-Rachid, T., Liu, S., Götz, T., Gao, L., Turrel, O., Maglione, M., Grieger, M., Putignano, S., Ramesh, N., Ghelani, T., Neumann, A., Gimber, N., Schmoranzer, J., Stawrakakis, A., Brence B., Baum, D., Ludwig, K., Heine, M., Mielke T., Liu, F., Walter, A. M., Wahl, M. C., Sigrist, S. J. (2025). Blobby is a synaptic active zone assembly protein required for memory in Drosophila. Nature Communications, 16. https://doi: 10.1038/s41467-024-55382-9
Woo M.S., Brand J., Bal L.C., Moritz M., Walkenhorst M., Vieira V., Ipenberg I., Rothammer N., Wang M., Dogan B., Loreth D., Mayer C., Nagel D., Wagner I., Pfeffer L.K., Landgraf P., van Ham M., Mattern K.M., Winschel I., Frantz N., Sonner J.K., Grosshans H.K., Miguela A., Bauer S., Meurs N., Müller A., Binkle-Ladisch L., Salinas G., Jänsch L., Dieterich D.C., Riedner M., Krüger E., Heppner F.L., Glatzel M., Puelles V.G., Engler J.B., Nyengaard J.R., Misgeld T., Kerschensteiner M., Merkler D., Meyer-Schwesinger C., Friese M.A. (2025). The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. Cell. 2025 13:S0092-8674(25)00616-6. doi: 10.1016/j.cell.2025.05.029. Epub ahead of print. PMID: 40532699
Hertrich N. , Han Y., Doil N., Ranti D. , Eickholt B., Konietzny A., Mikhaylova M. Myosin VI controls localization of Golgi satellites at active presynaptic boutons. Cel. Mol. Life Sciences, in press
Subkhangulov A., Mikhaylova M. Golgi apparatus: adaptations to neuronal shape and functions. EMBO J, in press
Walther J., Scalise A.C., Hertrich N., Augustin S., Vogt A., Jentsch T.J., Mikhaylova M., Vierock J. Lyso-pHrOG is a pH-regulating OptoGene for all-optical control of lysosomal pH and physiology. Nat. Comm. in press
PUBLICATIONS 2024
Arndt, H., Bachurski, M., Yuanxiang, P., Franke, K., Wessjohann, L.A., Kreutz, M. R., Grochowska, K. M. (2024). A Screen of Plant-Based Natural Products Revealed That Quercetin Prevents Pyroglutamylated Amyloid-β (Aβ3(pE)-42) Uptake in Astrocytes As Well As Resulting Astrogliosis and Synaptic Dysfunction. Molecular Neurobiology, 62(3), https://doi: 110.1007/s12035-024-04509-6
Bär, J., Fanutza, T., Reimann, C. C., Seipold, L., Grohe, M., Bolter, J. R., Delfs, F., Bucher, M., Gee, C. E., Schweizer, M., Saftig, P., Mikhaylova, M. (2024). Non-canonical function of ADAM10 in presynaptic plasticity. Cellular and Molecular Life Sciences, 81(1), https://doi: 10.1007/s00018-024-05327-8
Cavalli P., Raffauf A., Passarella S., Helmuth M., Dieterich D.C., Landgraf P. (2024). Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons. Frontiers in Cellular Neuroscience. 14;18:1465011. doi: 10.3389/fncel.2024.1465011. PMID: 39469305; PMCID: PMC11513877
Fernandez A., Corvalan K., Santis O., Mendez-Ruette M., Caviedes A., Pizarro M., Gomez M.T., Batiz L.F., Landgraf P., Kähne T., Rojas-Fernandez A., Wyneken U. (2024.) Sumoylation in astrocytes induces changes in the proteome of the derived small extracellular vesicles which change protein synthesis and dendrite morphology in target neurons. Brain Research 2024, 1823: 148679. doi: 10.1016/j.brainres.2023.148679. Epub 2023 Nov 14. PMID: 37972846
Grochowska K. M., Kreutz M. R. (2024). A liaison between chaperone-mediated autophagy and exocytotic lysosomes controls the dendritic metastable proteome. Autophagy. 2024 Feb;20(2):457-459. doi: 10.1080/15548627.2023.2274256
Konietzny, A., Han, Y., Popp, Y., Van Bommel, B., Sharma, A., Delagrange, P., Arbez, N., Moutin, M., Peris, L. & Mikhaylova, M. (2024). Efficient axonal transport of endolysosomes relies on the balanced ratio of microtubule tyrosination and detyrosination. Journal Of Cell Science, 137(8), https://doi.org/10.1242/jcs.261737
Krause, G. M., Chirich Barreira, L. M., Albrecht, A. (2024). Spatial mRNA expression patterns of orexin receptors in the dorsal hippocampus. Scientific Reports, 14(1), https://doi: 10.1038/s41598-024-76237-9
Passarella S., Kethiswaran S., Brandes K., Tsai I.C., Cebulski K., Kröger A., Dieterich D.C., Landgraf P.(2024). Alteration of cGAS-STING signaling pathway components in the mouse cortex and hippocampus during healthy brain aging. Frontiers in Aging Neuroscience 16:1429005. doi: 10.3389/fnagi.2024.1429005. PMID: 39149145; PMCID: PMC11324507
Tacke C., Landgraf P., Dieterich D.C., Kröger A. (2024). The fate of neuronal synapse homeostasis in aging, infection, and inflammation. American Journal of Physiology-Cell Physiology. 1;327(6):C1546-C1563. doi: 10.1152/ajpcell.00466.2024. Epub 2024 Nov 4. PMID: 39495249
Wirth, S., Schlößer, A., Beiersdorfer, A., Schweizer, M., Lohr, C., Grochowska, K. M. (2024). Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling. Glia, 72(8), https://doi: 10.1002/glia.24539
PUBLICATIONS 2023
Andres-Alonso, M., Borgmeyer, M., Mirzapourdelavar, H., Lormann, J., Klein, K., Schweizer, M., Hoffmeister-Ullerich, S., Oelschlegel, A. M., Dityatev, A., & Kreutz, M. R. (2023). Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses. Cell Reports, 42(7), 112692. https://doi.org/10.1016/j.celrep.2023.112692
Dutta, S., Linneweber, G. A., Andriatsilavo, M., Hiesinger, P. R., Hassan, B. (2023). EGFR-dependent suppression of synaptic autophagy is required for neuronal circuit development. Current Biology, 33(3), 517-532.e5. https://doi.org/10.1016/j.cub.2022.12.039
Hassan, B., Hiesinger, P. R. (2023). Autophagy in synapse formation and brain wiring. Autophagy, 19(10), 2814–2816. https://doi.org/10.1080/15548627.2023.2179778
Grochowska, K. M., Sperveslage, M., Raman, R., Failla, A. V., Głów, D., Schulze, C., Laprell, L., Fehse, B., & Kreutz, M. R. (2023). Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal. Cell Reports, 42(8), 112998. https://doi.org/10.1016/j.celrep.2023.112998
Grochowska, K. M., Gomes G. M., Raman, R., Kaushik, R., Sosulina, L., Kaneko, H., Oelschlegel, A. M., Yuanxiang, P., Reyes-Resina, I., Bayraktar, G., Samer S., Spilker, C., Woo, M. S., Morawski, M., Goldschmidt, J., Friese, M. A., Rossner, S., Brugal, G., Remy, S., Reissner, C., Karpova, A., Kreutz, M. R. (2023). Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer’s Disease. EMBO Journal, 42(4). https:// doi: 10.15252/embj.2022112453
Prabhakar P., Pielot R., Landgraf P., Wissing J., Bayrhammer A., van Ham M., Gundelfinger E.D., Jänsch L., Dieterich D.C., Müller A. (2023). Monitoring regional astrocyte diversity by cell type-specific proteomic labeling in vivo. Glia 2023 71(3): 682-703. doi: 10.1002/glia.24304. Epub 2022 Nov 19. PMID: 36401581
Ramesh N., Escher M., Turrel O., Lützkendorf J., Matkovic T., Liu F., Sigrist S.J. (2023). An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity. Elife. 2023 Sep 28;12:e86084. doi: 10.7554/eLife.86084. PMID: 37767892
Swietlik J. J., Bärthel S., Falcomatà C., Fink D., Sinha A., Cheng J., Ebner S., Landgraf P., Dieterich D.C., Daub H., Saur D., Meissner F. (2023). Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation. Nature Communications 2023 14(1): 2642. doi: 10.1038/s41467-023-38171-8. PMID: 37156840; PMCID: PMC10167354
Winkler, I., Engler, J. B., Vieira, V., Bauer, S., Liu, Y. H., Di Liberto, G., Grochowska, K. M., Wagner, I., Bier, J., Bal, L. C., Rothammer, N., Meurs, N., Egervari, K., Schattling, B., Salinas, G., Kreutz, M. R., Huang, Y. S., Pless, O., Merkler, D., Friese, M. A. (2023). MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration. Science Advances, 9(47). https://doi: 10.1126/sciadv.adi6855
Yperman, K., & Kuijpers, M. (2023b). Neuronal endoplasmic reticulum architecture and roles in axonal physiology. Molecular and Cellular Neuroscience, 125, 103822. https://doi.org/10.1016/j.mcn.2023.103822
PUBLICATIONS 2022
Tadić, J., Ring, J., Jerkovic, A., Ristic, S., Maglione, M., Dengjel, J., Sigrist, S. J., & Eisenberg, T. (2022b). A pathological role of the Hsp40 protein Ydj1/DnaJA1 in models of Alzheimer’s disease. Cell Stress, 6(5), 61–64. https://doi.org/10.15698/cst2022.05.267
Gundelfinger, E. D., Karpova, A., Pielot, R., Garner, C. C., Kreutz, M. R. (2022b). Organization of Presynaptic Autophagy-Related processes. Frontiers in Synaptic Neuroscience, 14. https://doi.org/10.3389/fnsyn.2022.829354
Piao C. and Sigrist S.J., (M)Unc13s in Active Zone Diversity: A Drosophila Perspective. Front Synaptic Neurosci. 2022 Jan 3:13:798204. doi: 10.3389/fnsyn.2021.798204. eCollection 2021.
Ring J., Tadic J., Ristic S., Poglitsch M., Bergmann M., Radic N., Mossmann D., Liang Y., Maglione M., Jerkovic A., Hajiraissi R., Hanke M., Küttner V., Wolinski H., Zimmermann A., Domuz Trifunović L., Mikolasch L., Moretti D.N., Broeskamp F., Westermayer J., Abraham C., Schauer S., Dammbrueck C., Hofer S.J., Abdellatif M., Grundmeier G., Kroemer G., Braun R.J., Hansen N., Sommer C., Ninkovic M., Seba S., Rockenfeller P., Vögtle F.N., Dengjel J., Meisinger C., Keller A., Sigrist S.J., Eisenberg T., Madeo F. (2022). The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. EMBO Mol Med. 2022 May 9;14(5):e13952. doi: 10.15252/emmm.202113952. Epub 2022 Apr 4. PMID: 35373908